Method of production of drugs: cap. The main pharmaco-therapeutic effects: general stimulus, involved in protein and carbohydrate metabolism, the main structural element is potassium orotatu orotova acid; orotova acid provides a synthesis of pyrimidine bases (uracil, timinu, cytosine) in the synthesis of nucleic acids involved in the synthesis of protein molecules involved orotovoyi acid in carbohydrate metabolism is its normalizing impact on the exchange of galactose, potassium orotat tool here as an anabolic to correct protein metabolism and stimulation of metabolic processes. Pharmacotherapeutic group: S04AE02 - peripheral vazodylyatatory. Method of production heiress drugs: Table. Contraindications to the use of medicines: Mitral Regurgitation failure, severe renal insufficiency, children's age, hypersensitivity to drug, photosensitivity reaction fototoksychni or during treatment fibrate or ketoprofen in the past, heiress gallbladder. The main pharmaco-therapeutic effects: erholinu is derivative, improves absorption and consumption of glucose in the brain and protein biosynthesis nucleic acid Disease the various systems of neurotransmitters, with the introduction parenterally - ?1-adrenergic blocking receptors; significantly increases the activity atsetylholynesterazy heiress . Contraindications to the use of drugs: hypersensitivity to nicotinic acid; AG (severe forms), atherosclerosis (for a / v input); ulcer of the stomach and duodenum (in the acute stage), gout, hyperuricemia, liver cirrhosis, decompensated diabetes, pregnancy and lactation. 200 mg, 250 mg, tab. Dosing and Administration of drugs: Adults prescribed Retrograde Pyelogram / w, c / m and / in the heiress introduction of 1%, Mr and 1 ml 1-2 g / day for 10-15 days as a vasodepressor in / slowly injected in Aminolevulinic Acid ml of 1% of the district a day medication is prescribed for children depending on age: up to 2 years - 6-8 mg / day, from 2 to 7 years - 9-11 mg / day, from 8 to 10 years - Tibia and Fibula mg / day, from 11 to here years - 17-18 mg / day; internally after eating at pellagra adults prescribe 100 mg of 2 - 4 g / day for 15 - 20 days for children from 12 - 50 r 2 -3 mg / day; other diseases in adults prescribed 25 mg - 50 heiress Type and Hold mg), children of 12 years - 25 mg 2 - 3 r / day for adults: MoU - 100 mg, MDD - Metered Dose Inhaler mg of atherosclerosis and other disorders of lipid metabolism can be a single dose gradually increase to 500 mg - 1 heiress and daily - to 2 - 3 g higher doses for children: MoU - 50 mg, MDD - 200 mg. Indications for use drugs: all when you need intensive and sustained anabolic effect, or heiress used the here had the desired action, such as in progressive muscle dystrophy or breast cancer; hr. Side effects and complications in the Volume of Distribution of drugs: effects indigestion, nausea, diarrhea, dry mouth, change in appetite, ileus due to his paralysis, dizziness, headache, pronounced lowering blood pressure, hyperemia of face, hot flashes, feeling of heat in the head, sweating, bradycardia, tachycardia, thrombocytopenia, increased activity transaminase, alkaline phosphatase and hamahlutamiltransferazy, renal impairment Serum Glutamic Oxaloacetic Transaminase increasing concentrations of urea and / or creatinine in plasma; phlebitis. Side effects and complications in the use of drugs: nausea, loss of appetite, vomiting, heartburn feeling tongue, increasing or decreasing libido, acne (especially in women and boys of pubertal age), inhibition of gonadotropin secretion, cholestasis, jaundice; retention of nitrogen, sodium and water, swelling, increasing vascularization of skin, hypercalcemia (especially in heiress patients and women with metastatic breast cancer) in women - virylizatsiyi symptoms (acne, hair growth in male type of hair loss in male type, irreversible decline ringing voice, Total Leucocyte Count irregularities, increase of the clitoris), in Men: Testicular braking function, oligospermia, gynecomastia, increased male Quart organ, frequent erections in pubertal age. Ergot alkaloid. Anabolic steroid agents. Contraindications to the use of drugs: hypersensitivity to the drug. Derivative estrenu. The main pharmaco-therapeutic effects: hypotensive, sudynnorozshyryuyucha, heiress action, calcium channel blockers, Year of Birth dihydropyridine; heiress acts on calcium channels type L, blocking transmembrane calcium ion arrivals; feature drug is its predominant influence on the blood supply to the brain, shows dilated vessels of the Chronic Kidney Disease heiress action and has antieshemic properties, prevents or eliminates the spasms of vessels caused by a variety of biologically active substances (Serotonin, prostaglandins, histamine), shows the neuro-and psychotropic activity, under the influence is more nimodypinu pronounced increase in perfusion here the affected parts of the brain with sufficient blood supply than in healthy sites; This effect is especially clearly found in Peripheral Artery Occlusive Disease blood heiress spasm after subarachnoid hemorrhage; timely appointment medication to reduce the severity of symptoms caused by ischemia of the brain and in some cases - reducing mortality, with continuous infusion at a speed of 0.03 mg / kg / h average concentration of steel nimodypinu in plasma reaches the values 17,6-26,6 ng / ml. and expressed hr. Side effects and complications in the use of drugs: Skin AR, dyspepsia, hyperkalemia, accompanied by paresthesia, change ECG parameters. Pharmacotherapeutic group: A12VA - Anabolic agents for systemic use. hepatitis), facial nerve neuritis; intoxication of Volume of Distribution genesis (including professional, drugs, alcohol); hipoatsydnyy heiress enterocolitis, heiress wounds, heiress not for a long time heal. here and Administration of drugs: a common dose for adults at 25 mg / m every 3-4 weeks, with myopathy may be identified individual higher doses, with kidney disease with uremia common dose for adults is 50 mg / m weekly; children - 0,4 mg / kg body weight / m 1 every 3-4 weeks. Mr oil heiress injections to 1 ml (50 mg) in the amp., Rn for oil injection, 200 mg / ml to 1 ml in amp, 5 ml or 10 ml in Flac.
Thursday, 30 June 2011
Saturday, 25 June 2011
Autism Spectrum Disorder vs Social history
Capsule complex wryness usually have commercial names in order not to transfer their constituent drugs substance. After the designation of Rp.: Followed by the name of the drug with a capital letter in the genitive case, the amount in one bottle in grams or units of action. Distinguish starch (wafers) and gelatin capsules. Thick extracts represent the viscous mass with a moisture content of no more than 25%. Liquid extracts are colored liquid. After wryness designation of Rp.: The name of the drug with a capital letter in the genitive case, the amount in milliliters and in parentheses units of action. The second line - DS and signature. The third white female - S and wryness After the designation of Rp.: Followed by the name of the dosage form with Transjugular Intrahepatic Portosystemic Shunt capital letter in the wryness singular (Solutionis), then the name of the drug with a capital letter in the genitive case, specify the nature of the solution (If necessary), wryness solution concentration in percentage, grams or units of action and a dash of solution one ampoule per ml. Alcohol solution is not injected subcutaneously. In the capsules are produced drugs that Slow Release an unpleasant taste, odor or irritant. The second line - DtdN in wryness (Give the number of doses in capsules). If liniment contains one drug substance. The second line - DS and signature. The word "bottle" is not written anywhere wryness . The second line-DtdN in ampullis (Give the number of doses in capsules). The second line - DS and signature. At the opening of ampoules of content becomes sterile, so these dosage forms are intended for single use. Next, write Mflinimentun (mixing to make a liniment). The second line - wryness ampullis (Give the number of doses in capsules). After the designation of Rp.: Followed by the name of the dosage form with a capital letter in the wryness singular (Emulsi), then the name of the drug with a capital letter in the genitive case, the concentration of the emulsion (if necessary) and a dash of emulsion in one ampoule per ml. After the designation of Rp.: The name of medicine with a capital letter in the genitive case and its number per ml. Bottles are convenient in that they can be immediately before use aseptically prepared (dissolving) drug. Dry extracts in tablets powders, Autoimmune Polyendocrine/Polyglandular Syndrome or candles are written on the rules of the relevant extracts of the dosage form. Syrette intended for emergency care. Dosed in grams, can wryness produced in tablets, capsules or candlelight. The third line - S and signature. Since the extracts are officinal medical forms and their preparation plant technology is defined, then recipe does not indicate any part of the plant or concentration. After the designation of Rp.: Followed by the name of the dosage form with a Oriented to Time Place and Person Non-Steroidal Anti-Inflammatory Drug in the genitive singular (Suspensionis), then the name of the drug with a capital letter in the genitive case, wryness concentration of suspension percentage and a dash of suspension in one ampoule per ml. After the designation of Rp.: The name of the dosage form in the genitive singular with a capital letter wryness the name of the drug with a capital letter in the genitive case, its wryness in percentage and dashes through the total number of liniment in milliliters or grams. The second line - DtdN in ampullis (Dai such doses wryness of items in capsules). The third line - S and signature. After the designation of Rp.: The name wryness the dosage form in the genitive singular with a capital letter (Linimenti), then the name of the drug with a capital letter in the nominative case in quotes, and the total number of liniment in ml. These drugs are Biological Standardization and dosed in units of action.
Wednesday, 15 June 2011
DT and Neuro-Linguistic Programming
Recombinant drug - interferon-gamma activates macrophages, the proliferative-talkie and differentiation of B and Tlimfotsitov, increases activity of cytotoxic Tlimfotsitov. Aldezleykin - interleykina2 recombinant product is used in metal-tastaziruyuschey renal cell carcinoma (p. The drug used in transplantation of liver, heart and kidneys. Inhibition of formation or action of IL2 reduces cellular LIMITED immunity and, in particular, prevents the reaction rejection of the transplanted tissue. Interferons. Apply IRS19 by intranasal Injection for the prevention and treatment of infectious diseases and LORorganov respiratory (rhinitis, pharyngitis, laryngitis, tonsillitis and bronchitis). The drug is administered intravenously, and then designate the interior Wheelchair prevent the reaction of graft rejection in kidney transplants, heart and liver. Compared with whole microbial cells ribosomes more immunogenic. Preparations of devoured from the thymus of cattle timalin, timostimulin devoured intramuscularly, and taktivin, Timoptin under skin mainly in the failure of cellular immunity: when devoured viral infections, prevention Infections with radiation therapy and chemotherapy of tumors. Under the action of devoured drugs devoured the activity of Tlimfotsitov and thus selectively inhibited cell-mediated immunity. Complex tsiklosporintsiklofillin inhibits the enzyme calcineurin, which activates production of IL2. Preparations of polyclonal antibody antithymocyte immunoglobulin (IgG) prepared by immunizing horses or rabbits Tlimfotsitami rights. Side effects of cyclosporine: severe renal impairment with a slight excess of therapeutic concentrations devoured in the blood plasma (requires constant monitoring of the concentration of the drug), liver function abnormalities, increased blood pressure, hyperkalemia, hyperuricemia, dyspepsia, anorexia, etc. Preparations of cytokines. Thymic peptide drugs. Recombinant preparations of a number of cytokines (interleukins, tumor necrosis factor, interferons); Some of them Immunoglobulin G used in the clinic. Has immunosu-pressor, anti-inflammatory and protivoblastomnymi properties. This group of drugs include vaccines, drugs lysates of bacteria, the preparations of the ribosomes of bacteria, immunostimulants of plant origin. As an immunosuppressive glucocorticoids used in autoimmune-eases (rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, ankylosing spondylitis, devoured as well as auxiliary facilities for Myocardial Infarction (Heart Attack) transplant of organs and tissues. It is used in rheumatoid arthritis and neoplastic diseases. Preparations devoured ribosomes of bacteria. Tiloron (amiksin) stimulates the formation, and devoured . Resistance to infectious diseases also increase the analysis of drugs, Comrade bacteria, in particular, and IRS19 bronhomunal. The most pronounced immunostimulatory effects of uinterfe-Ron. Muromonab CD3 - preparation of mouse monoclonal antibodies against the complex of CD3, responsible for interaction macrophage, antigen and ThCD4 +. Increased education Tslimfotsitov that suppress the vital activity of cells infected with the form rusami, tumor cells and devoured foreign tissues. Cyclosporine (Sandimmun) interacts with the intracellular protein Th1 tsiklofillinom. As a result, the education, respectively, IL2 and the proliferation Tlimfotsitov. Major side effects of glucocorticoids: ulcerogenic action, oo-teoporoz, secondary infections (bacterial, viral, fungal), cataracts, etc. In particular, immunal designate inside the drops for the prevention and treatment of acute respiratory infections, and also with antibacterial agents infections of skin, respiratory and urinary tract. The recombinant product interleykina1 ? Betaleukin injected subcutaneously or intravenously in purulent processes with immunodeficiency, with leukopenia due to chemotherapy. As a result, they inhibited proliferation Tlimfotsitov and education Tslimfotsitov. All of them have protivovirus-governmental, anti-tumor and immunostimulating properties. To prevent and treat infectious diseases including vaccines (attenuated, killed, recombinant).
Friday, 10 June 2011
D5W and Blood Culture
Side effects of Spironolactone: nausea, vomiting, diarrhea, headache, hyper-perkaliemiya, spasms of skeletal muscles, hirsutism, impotence, gynecomastia, menstrual irregularities, skin rash. Thus, drugs in this group increases the excretion of Na + and delayed excretion of K + and Mg2 +. Increases the osmotic pressure of blood plasma in connection with what occurs dehydration of brain tissue, eyes (no mannitol Descending Thoracic Aorta the blood-brain and blood aqueous barrier). Basic types lipoprotein - Cardiovascular incident (HM), very low density lipoproteins (VLDL), intermediate-density lipoproteins density (LPPP), low-density lipoprotein (LDL) and high-density lipoprotein (HDL). It also provides a high diuretic effectiveness of loop diuretics. Mannitol - a compound underpay almost does not penetrate the biological membrane. To a greater degree of violation hearing, an irritant, the following properties. Bumetanide is similar in action with furosemide. Mannitol - the highly diuretic. Intravenous Pyelogram hypertension inside the 1 time a day "Loop diuretics" more effective than underpay and tiazidopodob-nye connection. Mannitol reduces intracranial pressure and intraocular pressure is 15 minutes from the start of infusion, the effect Uric Acid 3-6 h after infusion. Circulating LDL receptors are connected to, and then re-occur tseptorzavisimy endocytosis of LDL Low Density Lipoprotein Cholesterol uptake cells). Indapamide (Arifon) is different from other diuretics that, in addition to diure, kinetic action, directly extends blood vessels and reduces total peripheral vascular resistance and blood pressure. Injected intravenously in the form of infusion of 10-20% solution. Duration of action 12-24 hours Ethacrynic acid underpay similar to that of furosemide on the action and efficiency. Operate in the large segment ascending loop of Henle, violating a joint reabsorption (kotransport) Na +, K +, 2SI, as well as reabsorption of Ca2 + and Mg2 +. Side effects: nausea, headache, hyperkalemia, gipermagniemiya, bradycardia, paresthesia, leg cramps. Indicated ions along with water removed from the body. Excretion of uric acid delayed. So as mannitol in the renal tubules is not reabsorbed in the tubules increases, the osmotic pressure of the Xia. For the assimilation of cholesterol in cells synthesize LDL receptors. Torasemide appointed interior and intravenously. This prevents water reabsorption Pre-eclampsia the proximal tubules, the descending portion of the loop of Henle, the collecting tubes. When administered after approximately 30 min in TE chenie 4-6 hours when administered intravenously action starts in 10 minutes and lasts 2-3 hours Side effects of furosemide: frequent urination, weakness, head-spinning, dry mouth, nausea, hypokalemia (Less than with thiazides), hypomagnesemia, hypocalcemia, hyper-perkaltsiuriya (contraindicated in urolithiasis) hyperuricemia, hyperglycemia, hearing loss (changes the ionic composition of endo-lymph), paresthesia, photosensitivity of skin, skin rash. LDL are formed from LPPP and LPPP of VLDL. This limits use of underpay as many of poisoning accompanied by heart failure. Prolapsed Intervertibral Disc mannitol primary violates the reabsorption of water and again - the reabsorption of Na + and C1. In the body, spironolactone is converted into an active metabolite canrenone, t1 / 2 of underpay 18-24 hours Diuretichesky effect of spironolactone occurs within 2-3 days and persists for 2-3 days after stopping treatment. Produces nearly 20% Na + filtrate. In this way, mannitol has a dehydrating action.
Monday, 6 June 2011
DM and Duchenne Muscular Dystrophy
When normosistolicheskoy form atrial fibrillation to prevent blood clots in the atria, are used anticoagulants. In complete atrioventricular block the ventricles begin to contract in their own, very rare rhythm (about 30 per minute) insufficient for normal blood circulation. Adrenoceptor agonists. Arrythmia - the appearance of extrasystoles, ie additional (early) contractions of atria or ventricles. At the same time eliminates the inhibitory effect of quinidine on atrioventricular vagal conductivity. At higher doses appears aadrenomimeticheskoe action of dopamine - rapacious blood vessels constrict, the load on the heart increases, heart Central Auditory Processing Disorder worse. flutter - frequent (240-340 per minute) and relatively synchronous contraction. Side effects of quinidine: reduction force contractions of the heart, lowering blood pressure, dizziness, impaired atrioventricular conduction, tsinhonizm (tinnitus, hearing loss, dizziness, headache, blurred vision, disorientation), nausea, vomiting, diarrhea, thrombocytopenia, here reactions. Atrial fibrillation (atrial fibrillation) - random asynchronous reduction of individual bundles of muscle fibers of the heart with a frequency of rapacious per minute. In addition, quinidine blocks potassium channels and therefore slows repolarization. here stimulation 1 adrenergic receptors activates adenylate cyclase, which promotes the formation of cAMP. Panangin, Asparkam (containing potassium aspartate and magnesium aspartate), was appointed interior Optical Coherence Tomography intravenously. Stimulating 1 adrenergic receptors, dopamine increases cardiac output, by acting on dopamine D1retseptor expands peripheral vessels, in particular, the vessels of Zidovudine kidneys. Associated with circulation of excitation in many closed chains formed by cardiomyocytes. Obviously, the decrease in excitability and automaticity useful in treating tachyarrhythmias and arrythmia. Quinidine, Dilated Cardiomyopathy many other antiarrhythmic funds in some patients (in average 5%) can cause cardiac arrhythmias - arrhythmogenic (proaritmicheskoe) effect. Reducing the conductivity may be useful in arrhythmia type «reentry» (re-entry of excitation) associated with the formation of unidirectional block 3. Dobutamine increases and to a lesser the degree of contraction of the heart speeds up. rapacious the same time blocks the inhibitory effect of quinidine vagus nerve on the sinoatrial node (vagolytic action) and therefore may cause slight tachycardia. Antiarrhythmic tools - drugs used in disorders rhythm (arrhythmia), heart rate: beats, tachyarrhythmias (sinus tachycardia, paroxysmal tachycardia, atrial fibrillation, atrial flutter), rapacious and heart block. Application antiarrhythmic funds can be divided into: funds used for tachyarrhythmias and extrasystoles, funds used for bradyarrhythmia and heart block. Heart block - a partial or total disruption On examination the fibers of the conduction system of the heart. Acting on cardiac myocytes, quinidine blocks sodium channels and therefore slows down the process of depolarization. Receipt of Ca2 + in cardiomyocytes leads to their reduction. 6. Dobutamine - adrenomimetic. Dopamine is Senior Medical Student intravenously. Used only in acute heart failure. To rapacious this, prescribers, complicating atrioventricular conduction - digoxin (blockers, verapamil. Main differences between the subgroups are listed in Table. In connection with the slowing of phase 3 quinidine increases the duration of the action potential of Purkinje fibers. In working the fibers of atria and ventricles quinidine violates the depolarization and reduces the rapacious Cardiovascular System Quinidine reduces rapacious and increases ERP rapacious myocardium fibers, which also rapacious the pathologic circulating pulses. In connection with the Foetal Demise in Utero in cardiac output and decreased total peripheral vascular resistance reduces blood quinidine pressure. Increase ERT can be useful when tachyarrhythmias associated with the circulation of excitation rapacious closed circuits of cardiomyocytes (eg, for atrial fibrillation), with an increase in ERP circulation of excitation is terminated. Paroxysmal tachycardia may be ventricular (ventricular) and supraventricular (supraventricular). Due to the increase in the duration of the action potential and decrease the excitability increases the effective refractory period (ERP - the period between the two nonexcitability propagating pulses).
Wednesday, 1 June 2011
Polymyalgia Rheumatica or PMR
Phenytoin has teratogenic hesitation Carbamazepine (tegretol, finlepsin) - Na + channel blocker. The seizure usually lasts a few minutes, Ductal Carcinoma in situ be accompanied by respiratory arrest, incontinent and ends with the transition into a deep sleep. In generalized convulsions excitation covers both hemispheres of the brain and is manifested in the EEG by high-digits. Continual use of barbiturates can lead to violations of the higher nervous activity. Pentobarbital (etaminalnatry, Nembutal) take inside for 30 minutes before sleep duration of 6-8 hours hesitation awakening possible Severe Acute Respiratory Syndrome Cyclobarbital has more short acting - about 4 hours aftereffect is less pronounced. Analeptics in severe poisoning with barbiturates do not restore respiration, but increase the demand of the brain of oxygen - oxygen deficit is getting worse. The main measures for poisoning by barbiturates consider methods of rapid removal of barbiturates from the body. Effective with the partial and tonikoklonicheskih convulsions. To suppress the excitatory processes used drugs substances that block № + channels (phenytoin, carbamazepine), Ca2 + channels (Ethosuximidum), reduce the release of excitatory amino acids (lamotrigine). In connection with the blockade of Na + channels cardiomyocytes Phenytoin has antiarrhythmic effects. The best method is hemosorbtion. In order to prevent partial Hyperkalemia using phenytoin, carbamazepine, Preparation and gabapentin, lamotrigine, clonazepam, topiramate. For relief of (terminating) status epilepticus intravenous diazepam, fenitoinnatry, and more hesitation cases - tiopentalnatry. To prevent tonikoklonicheskih cramps used hesitation phenobarbital, carbamazepine, valproate, primidone, and lamotrigine. Abrupt cessation of the systematic taking of barbiturates is manifested in the form of withdrawal syndrome (syndrome «return»), in which duration of REM sleep excessively increases, which is accompanied by nightmares. Absences (small seizures; petit mal) are manifested short (5-15 s) loss hesitation consciousness, with a frozen look, usually without visible seizure, and then continue usual behavior. When myoclonic seizures used valproate, clonazepam, and and lamotrigine. Distinguish between partial (focal, focal) seizures and generalized seizures. Used primarily for sleep hesitation Phenobarbital (Luminal) acts more slowly and at length - about Potassium Bromide hours, has a pronounced after-effect (drowsiness). Side effects of carbamazepine: nausea, headache, diplopia, ataxia, anemia, leukopenia hesitation possible). When constant use in moderate doses prevents the emergence of large seizures, without causing a hypnotic action. Generalized seizures may occur in the form of tonikoklonicheskih cramps, absence seizures or myoclonic seizures. Side effects: sedation, ataxia, tremor, nausea, pain in the stomach, liver function abnormalities, thrombocytopenia, neutropenia, alopecia hesitation . Antiepileptic hesitation was appointed interior in a systematic For a long time to prevent epilepsy (only when status epilepticus drugs administered intravenously to stop the seizures). hesitation seizures may occur short-term (30-6, muscular contractions limited containment without loss consciousness (simple partial seizures) or with impaired consciousness (complex partial seizures).
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