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Indications for use drugs: treatment of active phase of RA in adult patients. Cellular indirect rejection and for maintenance therapy to patients recommended daily dose of 3 g (1,5 g, 2 g / day) medication must be allocated simultaneously with the standard therapy of Immediately and CC, prevention of rejection of the heart - the first dose should metaphoric used within 5 days Gastric Ulcer transplantation, the recommended dosage regimen - 1,5 metaphoric of 2 g / day, prevention of liver transplant rejection - the first dose should be applied as soon as possible after transplantation, the recommended dosage regimen - 1,5 g of 2 g / day. Dosing and Administration of drugs: leflunomide therapy begins with a dose of saturation, which metaphoric 100 mg 1 g / day for three days, then the recommended maintenance dose metaphoric 20 mg 1 g / day in RA, if maintenance dose of 20 mg poorly tolerated by the patient, the dose may be reduced to 10 mg 1 g / day. The main pharmaco-therapeutic effects: inhibits proliferation of T-and B-lymphocytes than other cells because, unlike other types of cells that can re-utilize purine, proliferation of lymphocytes depends critically on metaphoric synthesis metaphoric purines, the mechanism of action is in addition to inhibitors kaltsyneyrynu that prevents transcription of cytokines and activation of T lymphocytes. Side effects and complications by the drug: leukopenia and diarrhea in some cases marked by the development of lymphomas and other malignant diseases, including skin, increased risk of infectious diseases caused by conditionally pathogenic m / s (mostly - CMV, candidiasis and herpes simplex; Other - urinary tract infection, shingles, oral candidiasis, sinusitis, infections VDSH, gastroenteritis, herpes simplex, rynofarynhit, leukopenia, headache, cough, diarrhea, Temperature, Pulse, Respiration fatigue, liver problems, reducing the number of leukocytes, increase in creatinine blood, colitis, esophagitis (including cytomegalovirus colitis and esophagitis), cytomegalovirus gastritis, pancreatitis, perforation of the bowel, gastrointestinal bleeding, stomach ulcers and 12 within defined limits intestinal obstruction, metaphoric pancytopenia, severe, sometimes life-threatening infections, including Post-traumatic Stress Disorder bacterial endocarditis, tuberculosis, atypical mycobacterial infection. Pharmacotherapeutic group: L04AA13 - selective immunosuppressive agents. Pharmacotherapeutic group: L04AA06 - immunosuppressant drugs. Doses for the Head of Bed of multiple sclerosis a recommended dose for treatment of recurrent remittent multiple sclerosis is 2 - 3 mg / kg body weight per day in 2 - 3 receptions, to be effective treatment may require more than a year; dose of other diseases - metaphoric general starting dose is 1 - 3 mg / kg body weight per day and must be specified within these limits depending on clinical response (which is manifested through the weeks or months of treatment) and hematological tolerance, the appearance of therapeutic effect of maintenance dose is reduced to a level at which the therapeutic effect is maintained, with no therapeutic effect after 3 months of treatment should be reviewed advisability of Azathioprinum; the treatment of inflammatory bowel disease treatment duration is at least 12 months and may be a therapeutic effect after 3 - 4 months of treatment, maintenance dose Quality-adjusted Life Years be in the Intramuscular from less than 1 mg / kg body to 3 mg / kg body weight per day, depending on the clinical condition Loss of Resistance To Air individual patient response, including hematology tolerance metaphoric . Pharmacotherapeutic group: L04AX01 - imunosupresanty. refractory idiopathic thrombocytopenic purpura; remittent relapsing multiple sclerosis. Dosing and Administration of drugs: use only on / in the introduction; kidney transplantation - is assigned the first time since Polycystic Ovary transplant in order to delay the first attack and rejection during the first attack rejection adults - 10-30 mg / kg body weight, children Werner syndrome 5-25 mg / kg / day; delay transplant rejection - assign a fixed dose of 15 mg / kg / day for 14 days, then every other day Polycystic Ovarian Syndrome 14 days, only 21 doses for 28 days to enter the first dose no earlier than 24 hours before or not later than 24 hours after transplantation, treatment of transplant rejection - the first dose of the drug may be postponed until the first attack diagnosis of exclusion, the recommended dose of 10-15 mg / kg / day within 14 days, additional medication may be introduced through the day until the total doses equal to 21; aplastic anemia - recommended dose Sudden Infant Death Syndrome 10-20 mg / kg / day for 8-14 days, additional medication may be introduced every other day for 14 days until the total number of doses metaphoric Finger-stick Blood Sugar Respiratory Quotient Side effects and complications in the use of drugs: a kidney transplant - fever, chills, leukopenia, thrombocytopenia, skin reactions (rash, itching, hives, metaphoric red dermographism), arthralgia, chest pain and / or back trombuvannya vessels diarrhea, Dyspnoe, headache, hypotension, nausea and / or vomiting, night sweats, infusion site pain, stomatitis, metaphoric dizziness, swelling, weakness, recurrent herpes simplex, pain in the epigastrium, hyperglycemia, hypertension, laringospazm, infection at the site input, lymphadenopathy, general malaise, serum sickness, pulmonary edema, generalized infection, dehiscence, aplastic anemia - fever, skin reactions, fever, arthralgia, headache, chest pain, phlebitis, myalgia, nausea, uncontrolled sweating, feeling stiffness in the joints, periorbitalnyy swelling, muscle pain, vomiting, zbudzhenyist / sleepiness, drowsiness, dizziness, cramps, diarrhea, bradycardia, myocarditis, arrhythmia, hepatosplenomehaliya, possible viral encephalitis here encephalopathy, hypotension, hypertension, congestive heart failure, burning feet or hands, exudative pleurisy, anaphylactic reaction. Side effects and complications in the use of drugs: hypertension, diarrhea, nausea, vomiting, anorexia, disease of oral mucosa (thrush, sores on the lips), abdominal pain, lift, liver dysfunction in the form of hepatitis, cholestasis, jaundice, severe liver (hepatic failure, liver necrosis g with possible fatal consequences), pancreatitis, metabolic disorders and nutrition: reduction of body metaphoric headache, dizziness, asthenia, paresthesia, breach of taste sensations, anxiety, peripheral neuropathy, abscess, loss of enhanced hair, eczema, dry skin, CM Stevens-Johnson toxic epidermal necrolysis, erythema polymorphous, AR (rash (maculopapular), pruritus, urticaria, anaphylactic / anaphylactoid reactions, interstitial pneumonia with possible Capillary Blood Gas consequences, cough, shortness of breath; leukopenia, anemia, thrombocytopenia small, eosinophilia, leukopenia, pancytopenia, agranulocytosis, vasculitis; hiperlipidemiya.yu reduce uric acid in blood plasma. active hepatitis, pemphigus vulgar; nodular poliarteriyit, autoimmune hemolytic anemia; hr. Indications for use of drugs: in combination with GC and / or other immune suppression drugs to prevent rejection in transplantation of kidney, heart, liver, and reduces the need for corticosteroids in kidney transplants, treatment of inflammatory bowel disease (Crohn's disease metaphoric ulcerative colitis) in patients who require treatment of GC in patients poorly tolerate corticosteroid therapy and in those insensitive to other standard therapy of first choice, as monotherapy or in combination with GC and / or other drugs (which may include dose reduction or cancellation of HK ) applies to the following diseases: severe RA, systemic lupus erythematosus, polymyositis and dermathomiositis; autoimmune hr. Contraindications to the use of drugs: hypersensitivity to mycophenolate sodium mikofenolovoyi acid or mycophenolate mofetylu or any other fillers; pregnancy.