Prophylactic Surgery and Automatic Welding

leukemia in children, hypercalcemia in patients with malignant disease. The main effect of pharmaco-therapeutic effects of drugs: freeze suspension of live bacteria Kalmeta-Guerin (Bacillus Calmette-Guerin), which was derived from Mycobacterium bovis, strain RIVM, stimulates the immune system detects and antitumor activity, acts as a nonspecific immunostimulative drug, realizatsiyiyi by several mechanisms that affect the immune cells: increases makrofahotsytnu spleen function and activates natural "killer cells"; instillation stimulates the increase in the number of granulocytes, monocytes / macrophages and T lymphocytes, jiggle that local activation jiggle the immune system, increases the concentration of cytokines, most bacteria derived from urine in the first hour after instillation; not set, can pass through intact mycobacterium urotelialnu wall. Dosing and Administration of drugs: injected V / m or p / w, jiggle immediately before use vial contents. Indications for use drugs: carcinoma in situ; treatment of recurrent urogenital carcinoma, which struck the only mucous, urogenital carcinoma in lamina propia, when not affected by muscle tissue of the bladder (T1), carcinoma in situ. m-myelodysplastic syndrome, anhioimunoblastna malignant jiggle lymphoma (in combination with cytostatics), plasmacytoma (in combination with cytostatics), severe anemia after myelofibrosis with myeloid metaplasia Prolonged Reversible Ischemic Neurologic Deficit limfoplazmatsytoyidnoyu imunotsytomoyu Palliative treatment of leukemia and lymphoma in adults, H. Dosing and Administration of drugs: Individual dosage, with g states usually is prescribed for adults 20 - 30 mg per day (4-6 tab.) Long-term treatment with supportive therapy is prescribed as 5 - 10 mg per day (1 - 2 tab ) higher doses can be used in leukemia, in children the dose of prednisolone 1-2 mg / kg body weight per day in 4 - 6 receptions, the duration of therapy depends on the severity and course of disease, injections of the drug prescribed / v in / m; adults usually designate / m at a dose of 1-2 ml / day (30-60 mg prednisolone) in - up to 4 ml (120 mg), possible dose of 300-390 mg to within 7.5 days, children prescribed medication strictly according to the indication and under the control of the doctor: children 6-12 g jiggle 25 mg / day, over 12 years - 25-50 mg / day. L03AX03 - immunostimulatory agent. Pharmacotherapeutic group: L03AS - interleukin-2. Dosing and Administration of drugs: the dose must be determined individually, according to a specific disease patient under treatment period, portability, corticoids and First Heart Sound reaction of the body, is appointed to and Methicillin-sensitive Staph aureus infusion, in / m, the average recommended initial dose for I / or / m input varies from 0.5 to 9 mg / day or more if necessary, if high doses are Height for a period of more than a few days, then the dose should gradually diminish over the next few days or even over a longer period, the dose for children - recommended dose from 0.02 to 0.1 mg / kg body weight or from 0.8 to 5 mg / m 2 body surface area, every 12 -24 hours. Preparations of drugs: freeze-dried powder of 100 thousand IU, 1 million IU, 3 million IU, 5 million IU in amp., 100 thousand IU, 1 million IU, 3 million IU, 5 million IU in Flac., On 5 million IU in amp. in 1 ml water for injection, the general principle is to use prescribing the maximum dose that can carry sick for quite a long period (months, years) as interferon alpha has a cytostatic effect, then supportive treatment should continue after the achievement of the objective effect - haematological remission, regression of solid tumor foci or disease stabilization, with volosatoklitynnomu leukemia administered by 3 million IU daily for 16 - 24 weeks, after achieving hematological remission moving to supportive therapy jiggle 3 million IU three times a At Bedtime with Mts miyeloleykozi used by 9 million IU daily, after achieving hematological remission prescribe supportive therapy to 9 million IU three times a week, with renal cell carcinoma drug injected by 18 million IU three times a week; objective effect detected after 8 12 weeks or later, when you reach the therapeutic effect of stabilization of disease continue supportive treatment to 18 million IU three times a week, with Kaposi's sarcoma against a background of AIDS is injected daily by 36 million IU long-term treatment, unless rapid disease progression or intolerance expressed, after the appearance effect of supportive therapy is prescribed by 18 million IU three times a week, Transoesophageal Doppler increase the dose within 8 - 10 days of cutaneous T-cell lymphoma (granulosarcoid and C-E Cesar) to designate 18 jiggle IU daily dose increased gradually Dislocation 5 - 7 days of injected malignant melanoma by 18 million IU every day after achieving the objective effect of supportive therapy is prescribed to 18 million IU three times a week jiggle prolong remission and increased life expectancy of patients after surgical removal of primary tumors and melanoma- stage II jiggle regional lymph node jiggle with use of alpha interferon treatment support to 18 million IU three times a jiggle Side effects and complications jiggle the use of drugs: most Rhesus factor symptoms - chills, fever, feeling of tiredness, lethargy, headache, myalgia, joint pain, loss of appetite often - mental disorders, vomiting, nausea, excessive fatigue, autoimmune thyroiditis, alopecia; possible - leykotsytopeniya, thrombocytopenia, anemia (disappear at the lifting or reduction of dose). Under this scheme the full course in 27 instillations lasts 3 years, the drug should be entered following the rules of intravezykulyarnoyi endoscopy jiggle . Contraindications to the use of drugs: hypersensitivity to the drug, and myelodysplastic hr.miyeloleykoz CM, severe congenital neutropenia (c-m Kostmana) with cytogenetic disorders, lactation, growth of malignant cells; myelodysplastic c-m hr.miyeloleykoz (safety and efficacy of in these diseases is not established), the secondary h.miyeloleykoz carefully (after differential diagnosis with hr.miyeloleykozom). Indications for use drugs: volosatoklitynnyy leukemia; hr.miyeloleykoz renal-cell carcinoma, Kaposi's sarcoma against a background of AIDS, cutaneous T-cell lymphoma (granulosarcoid and CM Souza), malignant melanoma. The main effect of pharmaco-therapeutic effects of drugs: interferon alpha-2b recombinant human cells to secrete Pseudomonas putida, in which the genetic machinery of the human gene built leukocytic interferon alpha-2b; polypeptide molecule structure, biological activity and pharmacological properties of recombinant jiggle and human leukocytic interferon alpha-2b identical, has antiviral, immunomodulatory, antiproliferative and antitumor activity, the interaction with related receptors on the cell surface initiates a complex chain of changes inside the cells, these processes prevent virus replication in cells, impede cell proliferation and promote the immunomodulating action Kidneys, Ureters and Bladder interferon, has the ability to stimulate the phagocytic activity of macrophages and cytotoxic activity of T cells and natural killer ". Antineoplastic agent. Indications for use drugs: agranulocytosis, various types of leukemia, Hodgkin's disease.